(xy)(x4y)(x-y)(x-4y)

1
Use the FOIL method: (a+b)(c+d)=ac+ad+bc+bd(a+b)(c+d)=ac+ad+bc+bd.
x24xyyx+4y2{x}^{2}-4xy-yx+4{y}^{2}

2
Collect like terms.
x2+(4xyxy)+4y2{x}^{2}+(-4xy-xy)+4{y}^{2}

3
Simplify.
x25xy+4y2{x}^{2}-5xy+4{y}^{2}

Done

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